个人简介

王浩，博士，2004年本科毕业于天津医科大学药学院，2009年硕士毕业于北京协和医学院药物化学专业，2012年博士毕业于北京协和医学院放射医学专业，2017-2020年哈佛大学医学院博士后。2021年加入天津大学医学工程与转化医学研究院，目前主要从事放射医学与生物医学工程领域研究工作。

主要研究方向

小分子药物及超小团簇分子的设计合成及其在疾病的诊断与治疗中的应用

代表性学术成果

1.       Hao Wang#, Xiaoyu Mu#, Jiang Yang#, Yongye Liang, Xiao-Dong Zhang, Dong Ming. Brain imaging with near-infrared fluorophores. Coordination Chemistry Reviews. 2019, 380:550-571.

2.        Hao Wang#, Xiaoyu Mu#, Hua He, Xiao-Dong Zhang. Cancer radiosensitizers. Trends in Pharmacological Sciences. 2018, 39 (1): 24-48.

3.        Wang H, Meng AM, Li SH, Zhou XL. A nanobody targeting Carcinoembryonic antigen as a promising molecular probe for Non-Small Cell Lung Cancer.  Molecular Medicine Reports. 2017, 16:  625-630.

4.        Wang H, Liu JJ, Zhou XL. Targeting assay of a fusion protein applied in enzyme prodrug therapy. Oncology Letters, 2017, 13(4):2698-702.

5.        Wang H, Shi PJ, Wu MF, Li N, Zhou XL, Fan FY. Construction, expression and functional characterization of the beta-lactamase with alphav integrin ligands. Protein & Peptide Letters. 2010, 17(12):1562-5.

6.        Wang H, Zhou XL, Long W, Liu JJ, Fan FY. A Fusion Protein of RGD4C and beta-Lactamase Has a Favorable Targeting Effect in Its Use in Antibody Directed Enzyme Prodrug Therapy. International Journal of Molecular Sciences. 2015, 16(5):9625-34.

7.        Zhou XL, Wang H, Shi PJ, Meng AM. Characterization of a fusion protein of RGD4C and the beta-lactamase variant for antibody-directed enzyme prodrug therapy. OncoTargets and Therapy. 2014, 7:535-41.

8.       Dong Yang, Hao Wang, Shenglin Luo, Changning Wang, Sheng Zhang, and Shiqi Guo. 2019. Paper-Cut Flexible Multifunctional Electronics Using MoS2 Nanosheet. Nanomaterials, 2019, 9(7):  922-937.

9.       Yulong Xu*, Yanli Wang, Hao Wang and Changning Wang*. Synthesis and Characterization of Carbon-11 Labeled Iloperidone for Imaging of α1-Adrenoceptor in Brain. Front. Mol. Biosci., 2020, 7: 586327.

10.   Hao Wang, Yu Lan, Ping Bai, Zude Chen, Shenglin Luo, Yulong Xu, Stephanie Fiedler, Robin Striar, Changning Wang. Radiosynthesis of [11C]EI1 for imaging EZH2 using positron emission tomography. Medicinal Chemistry Research. 2020, 2020, 29:2106–2111.

11.   Wei Long, Xiaoyu Mu, Jun-Ying Wang*, Fujuan Xu, Jiang Yang, Jingya Wang, Si Sun, Jing Chen, Yuan-Ming Sun1, Hao Wang* and Xiao-Dong Zhang*. Dislocation Engineered PtPdMo Alloy With Enhanced Antioxidant Activity for Intestinal Injury. Frontiers in Chemistry. 2019, 7:784.

科研项目

已完成项目：

2017.4-2020.3，天津市面上项目，β-内酰胺酶自杀基因的构建及其联合放疗治疗肿瘤的实验研究，项目负责人。

2014.1-2016.12，国家自然基金青年项目，β-内酰胺酶自杀基因系统的构建及其合并放疗治疗肿瘤的研究，项目负责人。

2013.12-2014.11，协和青年骨干教师基金，新型吲唑衍生物合成及其辐射防护作用的研究，项目负责人。            

2008.4-2011.3，天津市面上项目，靶向肿瘤放疗增敏剂—RGDFK-NIDA类化合物的研究，项目负责人。