田裕涛
个人简介
田裕涛，天津大学临床医学院副院长，教授，国家重点研发计划首席科学家。2011~2019年，美国宾夕法尼亚大学医学院生理系任博士后研究员和研究助理；2020年入职天津大学。研究方向为钾离子通道门控过程和调节机制，以及离子通道在神经系统，心血管系统，内分泌系统中重要的生理或病理功能。相关研究成果表于Nature Chemical Biology，PNAS，Journal of General Physiology等生理学领域顶级期刊及重要期刊，曾多次被邀请参加国际国内外会议并做报告。
主要研究方向
细胞电生理
1、通过膜片钳电生理记录，解析钾离子、氯离子等通过的门控动力学特征，探索离子通道的“结构-功能”关系。
2、通过分子动力学模拟技术的探索离子通道门控过程中的动态变化规律。
3、基于人工智能技术的离子通道蛋白分析、设计与改造，以及相关靶向分子的设计与虚拟筛选。
4、离子通道重要生理、病理机制研究及离子通道靶向药物开发。
5、基于目标离子通道神经物理调控（超声等）技术的开发与应用。
**欢迎对细胞电生理，生物物理，生物大分子设计感兴趣，具有分子生物、生物化学、计算化学、计算机等基础的同学加入研究组**
主讲课程
《生理学》，88学时，临床医学专业核心基础课
《普通生物学（医）》，48学时，“新医科”大类基础课程
《细胞电生理前沿（全英文）》，32学时，研究生选修课
代表性学术成果
代表性成果
1、Fenglian Liu#, Yu Dang#, Lu Li#, Hao Feng#, Jianlin Li, Haowei Wang, Xu Zhang, Zhe Zhang*, Sheng Ye*, Yutao Tian*, Qingfeng Chen* (2023) Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily, Nature Chemical Biology, 2023, 19(10): 1276-1285
2、Yutao Tian*, Stefan H Heinemann, Toshinori Hoshi* (2019) Large-conductance Ca2+- and voltage-gated K+ channels form and break interactions with membrane lipids during each gating cycle. Proc Natl Acad Sci USA. 116 (17), 8591-8596. PMID: 30967508
3、Yutao Tian*, Marius Aursnes, Trond Vidar Hansen, Jørn Eivind Tungen, Jason D Galpin, Lilia Leisle, Christopher A Ahern, Rong Xu, Stefan H Heinemann, Toshinori Hoshi* (2016) Atomic determinants of BK channel activation by polyunsaturated fatty acids. Proc Natl Acad Sci USA 113 (48), 13905-13910. PMID: 27849612.
4、Yutao Tian*, Florian Ullrich, Rong Xu, Stefan H Heinemann, Shangwei Hou, Toshinori Hoshi* (2015) Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels. J Gen Physiol 145 (4), 331-343. PMID: 25825171.
5、Toshinori Hoshi*, Yutao Tian, Rong Xu, Stefan H Heinemann, Shangwei Hou (2013) Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. Proc Natl Acad Sci USA 110 (12), 4822-4827.PMID: 23487786.
6、Toshinori Hoshi*, Bianka Wissuwa, Yutao Tian, Nobuyoshi Tajima, Rong Xu, Michael Bauer, Stefan H Heinemann, Shangwei Hou (2013) Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca2+-dependent K+ channels. Proc Natl Acad Sci USA 110 (12), 4816-4821. PMID: 23487785.
其他成果
1、Yujiao Sun, Chao Chang, Zhenhua Wu, Yifei Zhang*, Yutao Tian*. Role and (2024) Mechanism of Polyunsaturated Fatty Acids on Potassium Ion Channels. Prog. Biochem. Biophys. 51(1): 5-19
2、王伯展, 栗鑫, 杨佳佳, 田裕涛*. 基于机械敏感离子通道的超声神经调制研究进展. (2023) 生物工程学报, 39(10): 4029-4045
3、Kevin A Strauss*, Sander Markx, Benjamin Georgi, Steven M Paul, Robert N Jinks, Toshinori Hoshi, Ann McDonald, Michael B First, Wencheng Liu, Abigail R Benkert, Adam D Heaps, Yutao Tian, Aravinda Chakravarti, Maja Bucan, Erik G Puffenberger (2014) A population-based study of KCNH7 p. Arg394His and bipolar spectrum disorder. Hum Mol Genet 23 (23), 6395-6406. PMID: PMID: 2498691.
4、Toshinori Hoshi*, Rong Xu, Shangwei Hou, Stefan H Heinemann, Yutao Tian (2013) A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. J Gen Physiol 142 (5), 507-522. PMID: 24127525.
5、Yutao Tian, Ting Lei, Zhuo Yang, Tao Zhang* (2012) Urethane suppresses hippocampal CA1 neuron excitability via changes in presynaptic glutamate release and in potassium channel activity. Brain Res Bull 87 (4-5), 420-426. PMID: 22314371.
6、Meina Quan, Chenguang Zheng, Nan Zhang, Dadong Han, Yutao Tian, Tao Zhang, Zhuo Yang* (2011) Impairments of behavior, information flow between thalamus and cortex, and prefrontal cortical synaptic plasticity in an animal model of depression. Brain Res Bull 85 (3-4), 109-116. PMID: 21396989.
7、Dadong Han, Yutao Tian, Tao Zhang, Guogang Ren, Zhuo Yang* (2011) Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats. Int J Nanomedicine 6, 1453. PMID: 21796247.
8、Yutao Tian, Zhuo Yang, Tao Zhang* (2011) Zinc ion as modulator effects on excitability and synaptic transmission in hippocampal CA1 neurons in Wistar rats. Neurosci Res 68 (3), 167-175. PMID: 20637810.
9、Meina Quan, Yutao Tian, Kunhan Xu, Tao Zhang, Zhuo Yang* (2010) Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats. Neuroscience 169 (1), 214-222. PMID: 20438813.
10、Jiajia Yang, Yutao Tian, Zhuo Yang, Tao Zhang* (2010) Effect of melamine on potassium currents in rat hippocampal CA1 neurons. Toxicol in Vitro 24 (2), 397-403. PMID: 19895883.
11、Yutao Tian, Zhaowei Liu, Yang Yao, Zhuo Yang, Tao Zhang* (2009) Effect of alpha-cypermethrin and theta-cypermethrin on delayed rectifier potassium currents in rat hippocampal neurons. Neurotoxicology 30 (2), 269-273. PMID: 19459223.
12、Yutao Tian, Zhaowei Liu, Yang Yao, Tao Zhang*, Zhuo Yang* (2008) Effects of alpha-and theta-cypermethrin insecticide on transient outward potassium current in rat hippocampal CA3 neurons. Pestic Biochem Physiol 90 (1), 1-7.
科研项目
1、国家重点研发计划，基于微弱物理场激励的细胞快速响应通讯元件精
准构建技术，2023/11-2026/10（在研；1400万；项目负责人）
2、国家自然科学基金面上项目，Slo1 BK通道选择性滤器门控过程及调节机制的研究，2021/01-2024/12（在研；59万；项目负责人）
3、创新项目，XXXXXXX，2020/07-2023/02（结题；项目负责人）