研究方向：神经病学，神经康复，智能医学

个人简介：

巫嘉陵，男，主任医师，教授，天津市环湖医院副院长,神经内科专家组组长。天津医科大学临床医学博士，美国Emory大学博士后；南开大学、天津医科大学博士研究生导师。天津市有突出贡献专家，天津市优秀科技工作者，首届“津门医学英才”，天津市 131 创新型人才”第一层次。

目前的学术任职包括：中国卒中学会理事、中国医师协会神经内科医师分会委员、天津市神经内科质控中心主任、天津市医学会神经病学分会副主任委员。

近五年主持国家级项目 4 项，市部级项目 4 项；获得市部级科技进步奖二等奖 1 项（第一完成人）；授权实用新型专利 2 项，发明专利 1 项；以通讯作者发表论文 46 篇，其中 SCI 21 篇，核心期刊 25 篇。

代表性学术成果：（论文）

1．Geng YQ, Qiu LN, Cheng YQ, Li JJ, Ma YL, Zhao CC, Cai Y, Zhang XB, Chen J, Pan YC, Wang KR, Yao XH, Guo DS, Wu JL. Alleviating Recombinant Tissue Plasminogen Activator-induced Hemorrhagic Transformation in Ischemic Stroke via Targeted Delivery of a Ferroptosis Inhibitor. Adv Sci (Weinh). 2024 Apr 22:e2309517.

2．Hou W, Wu F, Wang Y, Li W, Cheng Y, Zhu Z, Liang S, Liu P, Yu Y, Wu J. Predicting slight freezing of gait in Parkinson's disease with anticipatory postural adjustments and limits of stability. Parkinsonism Relat Disord. 2024 Mar 29;123:106949.

3．Zhang Z, Wang Y, Wang J, Cai Y, Liu P, Liu S, Wu J, Xie X. The role of peripheral inflammation-related biomarkers in distinguishing Parkinson's disease. Parkinsonism Relat Disord. 2024 Mar 16;123:106102.

4．Shu Z, Wang J, Cheng Y, Lu J, Lin J, Wang Y, Zhang X, Yu Y, Zhu Z, Han J, Wu J, Yu N. fNIRS-based graph frequency analysis to identify mild cognitive impairment in Parkinson's disease. J Neurosci Methods. 2024 Feb;402:110031.

5．Zheng J, Ma Y, Guo X, Wu J. Immunological characterization of stroke-heart syndrome and identification of inflammatory therapeutic targets. Front Immunol. 2023 Oct 30;14:1227104.

6．Zhang Z, Xie X, Cai Y, Liu P, Liu S, Chen R, Wang J, Wang Y, Zhao Y, Zhu Z, Zhang X, Wu J. Abnormal immune function of B lymphocyte in peripheral blood of Parkinson's disease. Parkinsonism Relat Disord. 2023 Nov;116:105890.

7．Shu Z, Wu J, Li H, Liu J, Lu J, Lin J, Liang S, Wu J, Han J, Yu N. fNIRS-based functional connectivity signifies recovery in patients with disorders of consciousness after DBS treatment. Clin Neurophysiol. 2023 Mar;147:60-68.

8．Sun Y, Cheng Y, You Y, Wang Y, Zhu Z, Yu Y, Han J, Wu J, Yu N. A novel plantar pressure analysis method to signify gait dynamics in Parkinson's disease. Math Biosci Eng. 2023 Jun 13;20(8):13474-13490.

9．Shu Z, Wu J, Lu J, Li H, Liu J, Lin J, Liang S, Wu J, Han J, Yu N. Effective DBS treatment improves neural information transmission of patients with disorders of consciousness: an fNIRS study. Physiol Meas. 2023 Dec 29;44(12).

10．Wang Y, Yu N, Lu J, Zhang X, Wang J, Shu Z, Cheng Y, Zhu Z, Yu Y, Liu P, Han J, Wu J*. Increased Effective Connectivity of the Left Parietal Lobe During Walking Tasks in Parkinson's Disease. J Parkinsons Dis. 2023;13(2):165-178.

11．Wang Y, Li Y, Liu S, Liu P, Zhu Z, Wu J*. Gait characteristics related to fall risk in patients with cerebral small vessel disease. Front Neurol. 2023 Jun 6;14:1166151.

12．Qiu L, Cai Y, Geng Y, Yao X, Wang L, Cao H, Zhang X, Wu Q, Kong D, Ding D, Shi Y, Wang Y, Wu J*. Mesenchymal stem cell-derived extracellular vesicles attenuate tPA-induced blood-brain barrier disruption in murine ischemic stroke models. Acta Biomater. 2022 Dec;154:424-442

13．Zhang X, Wang Y, Lu J, Wang J, Shu Z, Cheng Y, Zhu Z, Liu P, Yu Y, Yu N, Han J, Wu J*. Fronto-parietal cortex activation during walking in patients with Parkinson's disease adopting different postural strategies. Front Neurol. 2022 Oct 24;13:998243.

14．Liu P, Yu N, Yang Y, Yu Y, Sun X, Yu H, Han J, Wu J*. Quantitative assessment of gait characteristics in patients with Parkinson's disease using 2D video. Parkinsonism Relat Disord. 2022 Aug;101:49-56.

15．Lu J, Wang Y, Shu Z, Zhang X, Wang J, Cheng Y, Zhu Z, Yu Y, Wu J*, Han J*, Yu N*. fNIRS-based brain state transition features to signify functional degeneration after Parkinson's disease. J Neural Eng. 2022 Aug 12;19(4).

16．Yu N, Yu Y, Lin J, Yang Y, Wu J, Liang S*, Wu J*, Han J*. A non-contact system for intraoperative quantitative assessment of bradykinesia in deep brain stimulation surgery. Comput Methods Programs Biomed. 2022 Jul 5;225:107005.

17．Wang W, Wei M, Cheng Y, Zhao H, Du H, Hou W, Yu Y, Zhu Z, Qiu L, Zhang T, Wu J*. Safety and Efficacy of Early Rehabilitation After Stroke Using Mechanical Thrombectomy: A Pilot Randomized Controlled Trial. Front Neurol. 2022 Apr 8;13:698439.

18．Sun Y, Liang S, Yu Y, Yang Y, Lu J, Wu J, Cheng Y, Wang Y, Wu J*, Han J*, Yu N*. Plantar pressure-based temporal analysis of gait disturbance in idiopathic normal pressure hydrocephalus: Indications from a pilot longitudinal study. Comput Methods Programs Biomed. 2022 Apr;217:106691.

19．Mu L, Jiang L, Chen J, Xiao M, Wang W, Liu P, Wu J*. Serum Inflammatory Factors and Oxidative Stress Factors Are Associated With Increased Risk of Frailty and Cognitive Frailty in Patients With Cerebral Small Vessel Disease. Front Neurol. 2022 Jan 6;12:786277.

20．Jin W, Wu Y, Chen N, Wang Q, Wang Y, Li Y, Li S, Han X, Yang E, Tong F, Wu J*, Yuan X*, Kang C*. Early administration of MPC-n(IVIg) selectively accumulates in ischemic areas to protect inflammation-induced brain damage from ischemic stroke. Theranostics. 2021 Jul 13;11(17):8197-8217. 

21．Yu Y, Liang S*, Wang Y, Zhao Y, Zhao J, Li H, Wu J, Cheng Y, Wu F, Wu J*. Quantitative Analysis of Postural Instability in Patients with Parkinson's Disease. Parkinsons Dis. 2021 Apr 13;2021:5681870. doi: 10.1155/2021/5681870.（

22．Wang S, Song X, Wang Y, Gao Y, Wu J*. Elevated high-sensitivity C-reactive protein levels predict poor outcomes among patients with acute cardioembolic stroke. Ann Palliat Med. 2021 Feb 11:apm-20-1927.

23．Cai Y, Yang E, Yao X, Zhang X, Wang Q, Wang Y, Liu J, Fan W, Yi K, Kang C*, Wu J*. FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury. Redox Biol. 2021 ,38:101792.

24．Xue J, Ren F, Sun X, Yin M, Wu J*, Ma C, Gao Z. A Multifrequency Brain Network-Based Deep Learning Framework for Motor Imagery Decoding. Neural Plast. 2020 Dec 7;2020:8863223.

25．Liu P, Liu S, Feng N, Wang Y, Gao Y, Wu J*. Association between neurological deterioration and outcomes in patients with stroke. Ann Transl Med. 2020,8(1):4.

26．Yang E, Cai Y, Yao X, Liu J, Wang Q, Jin W, Wu Q, Fan W, Qiu L, Kang C*, Wu J*. Tissue plasminogen activator disrupts the blood-brain barrier through increasing the inflammatory response mediated by pericytes after cerebral ischemia. Aging (Albany NY). 2019 Nov 18;11(22):10167-10182. doi: 10.18632/aging.102431. Epub 2019 Nov 18.

科研项目：

已完成项目：（近五年）

在研项目：

获奖情况：

2019年天津市科学技术进步二等奖-基于病因分型的脑小动脉闭塞预后评估及精准康复治疗

社会学术兼职：

中国卒中学会青年理事会，常务理事；

中国卒中学会，理事；

中国医师协会神经内科医师分会，委员

天津市神经内科质控中心，主任；

天津市医学会神经病学分会，副主任委员；

《中国现代神经疾病杂志》，副主编