Jinrui Dong
Title/Position:Associate Professor
Research Areas:Mechanisms of tissue repair and regeneration and novel drug discovery
Email:jinrui_dong@tju.edu.cn
Brief Introduction:
Our group mainly focus on studying the mechanisms of tissue repair and regeneration, and development of novel drug for the treatment of disease. Recently, we have published 12 SCI papers as first or corresponding author, including Science Translational Medicine, Nature Communications, etc., with a cumulative impact factor of >150, as well as co-authored papers including Circulation (IF: 39.918), Gastroenterology (IF: 33.883), etc., with a cumulative impact factor of >350. I have become the member of American Thoracic Society, European Respiratory Society, Singapore Pharmacology Society, and Chinese Pharmacology Society, and appointed as a young editorial board member of Military Medical Research. In 2021, I have been selected in the "Beiyang Scholars Talent Program" of Tianjin University, and in 2023, I have been selected in the "Qiming Program" of Tianjin University to cultivate scientific and technological leaders and innovators. I have undertaken multiple projects including National Natural Science Foundation of China, Tianjin Natural Science Foundation of Tianjin, Education Commission of Tianjin, and university-industry cooperation.
Academic Achievements:
1. Lyu HH*, Li P, Dong JR*, et al. (2024) Pyrolysis temperature matters: Biochar-derived dissolved organic matter modulates aging behavior and biotoxicity of microplastics. Water Research.【IF: 13.3;Co-corresponding author】
2. Dong JR#, Li P#, Ji XY, et al. (2023) Electrons of d-orbital (Mn) and p-orbital (N) enhance the photocatalytic degradation of antibiotics by biochar while maintaining biocompatibility: a combined chemical and biological analysis. Journal of Hazardous Materials.【IF: 13.6】
3. Yuan X#, Kang Y#, Dong JR#, et al. (2023) Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy. Nature Communications.【IF: 16.6;Co-first author】
4. Kang Y, Xu LL, Dong JR*,..., Ji XY*. (2023) Calcium-based nanotechnology for cancer therapy. Coordination Chemistry Reviews. 【IF: 20.6;Co-corresponding author】
5. Dong JR, Lim WW, Shekeran SG, et al. (2022) Hepatocyte specific gp130 signalling underlies APAP induced liver injury. International Journal of Molecular Sciences.【IF: 5.6】
6. Dong JR, Viswanathan S, Adami E, et al. (2021) Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nature Communications.【IF: 16.6】
7. Widjaja AA#, Dong JR#, Adami E, et al. (2021) Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. Science Translational Medicine.【IF: 17.1;Co-first author】
8. Dong JR, Viswanathan S, Adami E, et al. (2021) The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. eLife.【IF: 7.7】
9. Ng B#, Dong JR#, D’Agostino G#, et al. (2019) Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis. Science Translational Medicine.【IF: 17.1】
10. Dong JR#, Liao WP#, Tan LH, et al. (2019) Gene silencing of receptor-interacting protein 2 protects against cigarette smoke-induced acute lung injury. Pharmacological Research.【IF: 9.3】
11. Dong JR, Liao WP, Peh HY, et al. (2018) Ribosomal Protein S3 gene silencing protects against cigarette smoke-induced acute lung injury. Molecular Therapy-Nucleic Acids.【IF: 8.8】
12. Dong JR, Liao WP, Peh HY, et al. (2017) Ribosomal Protein S3 gene silencing protects against experimental allergic asthma. British Journal of Pharmacology.【IF: 7.3】
Honors & Awards:
1. Best Poster Scientific Presentation Award of International Conference on Scientific Frontiers in Natural Product Based Drugs (2017)
2. Best Poster Presentation Award of 7th NUS Medicine Annual Graduate Scientific Congress (2017)
3. Best Poster Presentation Award of 6th NUS Medicine Annual Graduate Scientific Congress (2016)