穆晓宇
个人简介：
天津大学副研究员，硕士生导师，毕业于天津大学并获得博士学位。研究方向是新型生物医用材料与器件，其研究工作主要集中在生物医用材料与器件研发、红外二区的荧光成像及其在重大神经系统疾病治疗中的应用。迄今为止，在高水平SCI期刊共发表论文60余篇，其中以第一或通讯作者身份发表23篇，包含顶级期刊Nature Communication （Nature子刊）、 Science Advances （Science子刊）、ACS Nano、Nano Lett.、Coord. Chem. Rev.、Trends Pharmacol. Sci.、Theranostics和Small等，ESI高被引1篇，热点论文4篇。主持国家自然科学基金青年基金1项、国家重点研发计划子课题1项；作为项目骨干，参与“脑科学与类脑研究”重大项目青年科学家项目1项，国家自然科学基金重点项目、重大研究计划等4项；合作主持天津市自然科学基金面上项目2项。
主要研究方向：
1. 具有生物活性的新型催化材料的设计及其增强催化机理研究。
2. 便携性、微型纳米生物传感器的设计及其在重大疾病诊疗中的应用。
3. 新型干电极设计及其与组织界面间电子输运机制研究。
主讲课程：
大学物理A（本科生）
大学物理B（本科生）
大学物理实验（本科生）
社会学术兼职：
1. 中国毒理学会放射医学专委会 青年委员
2. 天津市生物医学工程学会纳米生物医学专委会 秘书
3. 国际SCI期刊Frontiers in Chemistry 编委
4. 国际SCI期刊Journal of Functional Biomaterials 编委
5. 国际知名期刊Nano Biomedicine and Engineering 青年编委
代表性学术成果：
1. Ke Chen#, Guo Li#, Xiaoqun Gong#, Qinjuan Ren, Junying Wang, Shuang Zhao, Ling Liu, Yuxing Yan, Qingshan Liu, Yang Cao, Yaoyao Ren, Qiong Qin, Qi Xin, Shulin Liu, Peiyu Yao, Bo Zhang, Jingkai Yang, Ruoli Zhao, Yuan Li, Ran Luo, Yikai Fu, Yonghui Li, Wei Long, Shu Zhang, Haitao Dai, Changlong Liu, Jianning Zhang, Jin Chang, Xiaoyu Mu*, & Xiao-Dong Zhang*, Atomic-scale strain engineering of atomically resolved Pt clusters transcending natural enzymes. Nature Communications, 2024, 15, 8346. (原子应力工程调控Pt团簇活性，基于此研发的便携式试剂盒实现了临床肿瘤患者的精准快速诊断)
https://www.nature.com/articles/s41467-024-52684-w
2. Xiaoyu Mu, Junying Wang, Hua He, Qifeng Li, Bing Yang, Junhui Wang, Haile Liu, Yalong Gao, Lufei Ouyang, Si Sun, Qinjuan Ren, Xinjian Shi, Wenting Hao, Qiaoman Fei, Jiang Yang, Lulin Li, Ryan Vest, Tony Wyss-Coray, Jian Luo, and Xiao-Dong Zhang*, An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury. Science Advances, 2021 (设计了具有超快电子转移的短聚物纳米酶，可以缓解急性脑损伤症状)。
https://www.science.org/doi/full/10.1126/sciadv.abk1210
3. Xiaoyu Liu#, Zhen Wan#, Ke Chen#, Yuxing Yan, Xuyan Li, Yili Wang, Miaoyu Wang, Ruoli Zhao, Jiahui Pei, Lijie Zhang, Si Sun, Jiarong Li, Xinzhu Chen, Qi Xin, Shaofang Zhang, Shuangjie Liu, Hao Wang, Changlong Liu*, Xiaoyu Mu*, Xiao-Dong Zhang*, Mated-Atom Nanozymes with Efficient Assisted NAD+ Replenishment for Skin Regeneration, Nano Letters, 2024, 24, 4924-4935.
4. Kaijin Liu#, Jiaxue Niu#, Ling Liu, Fangzhen Tian, Hongmei Nie, Xiaoyu Liu, Ke Chen, Ruoli Zhao, Si Sun, Menglu Jiao, Maoye Tian, Xinyu Sun, Lanfei Niu, Xinyi Sun, Hao Wang, Wei Long, Liefeng Feng*, Xiaoyu Mu*, Xiao-Dong Zhang*, LUMO-Mediated Se and HOMO-Mediated Te Nanozymes for Selective Redox Biocatalysis, Nano Letters, 2023, 23, 5131−5140.
5. Xiaoyu Mu; Hua He; Junying Wang; Wei Long; Qifeng Li; Haile Liu; Yalong Gao; Lufei Ouyang; Qinjuan Ren; Si Sun; Jingya Wang; Jiang Yang; Qiang Liu; Yuanming Sun; Changlong Liu; Xiaodong Zhang*; Wenping Hu, Carbogenic Nanozyme with Ultrahigh RNS Selectivity for Traumatic Brain Injury. Nano Lett. 2019, 19, 4527-4534.
6. Xiaoyu Mu; Junying Wang; Yonghui Li; Fujuan Xu; Wei Long; Lufei Ouyang; Haile Liu; Yaqi Jing; Jingya Wang; Haitao Dai; Qiang Liu; Yuanming Sun; Changlong Liu; Xiao-Dong Zhang*, Redox Trimetallic Nanozyme with Neutral Environment Preference for Brain Injury. ACS Nano 2019, 13, 1870-1884.
7. Hao Wang#; Xiaoyu Mu#; Jiang Yang; Yongye Liang; Xiao-Dong Zhang*; Dong Ming*, Brain Imaging with Near-Infrared Fluorophores. Coord. Chem. Rev. 2019, 380, 550-571. (co-First)
8. Hao Wang#; Xiaoyu Mu#; Hua He; Xiao-Dong Zhang*, Cancer Radiosensitizers. Trends Pharmacol. Sci. 2018, 39, 24-48. (co-First，热点论文0.1%，ESI高被引论文)
9. Menglu Jiao#, Xiaoyu Mu#, Si Sun#, Haiyu Yang, Lufei Ouyang, Shaofang Zhang, Jiao Guo, Jian Meng, Ya Liu, Huizhen Ma, Hao Wang, Jiahui Pei, Ruoli Zhao, Tianyu Liu, Wei Long, Xiao-Dong Zhang*, Ruiping Zhang*, Establishing bilateral modulation of radiation induced redox damage via biocatalytic single atom engineering at Au clusters, Chemical Engineering Journal, 2022, 445, 136793. (co-First)
10. Shaofang Zhang; Ying Liu; Si Sun; Junying Wang; Qifeng Li; Ruijuan Yan; Yalong Gao; Haile Liu; Shuangjie Liu; Wenting Hao; Haitao Dai; Changlong Liu; Yuanming Sun; Wei Long; Xiaoyu Mu*; Xiao-Dong Zhang*, Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain trauma. Theragnostic, 2021, 11, 2806-2821.
11. Shaofang Zhang, Yonghui Li, Si Sun, Ling Liu, Xiaoyu Mu, Shuhu Liu, Menglu Jiao, Xinzhu Chen, Ke Chen, Huizhen Ma, Tuo Li, Xiaoyu Liu, Hao Wang, Jianning Zhang, Jiang Yang & Xiao-Dong Zhang*, Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma, Nature Communications, 2022 (设计了超越天然酶亲和力的单原子纳米酶).
https://www.nature.com/articles/s41467-022-32411-z
http://news.tju.edu.cn/info/1012/61947.htm
12. Qingshan Liu#, Xuyan Li#, Yili Wang#, Xiaoyu Liu, Yang Cao, Hao Zhang, Xiaoyu Mu*, Xiaodong Zhang*, Neutrophil hitchhiking for nanoparticle delivery to the central nervous system, Applied Materials Today, 2024, 38, 102259.
13. Yunguang Zhang; Simin Ni; Chenyang Chong; Jiangang Xu∗; Xiaoyu Mu∗; Xiao-Dong Zhang∗, Biocatalysts at atom level: From coordination structure to medical applications. Appl. Mater. Today. 2021, 23, 101029.
14. Xiaoyu Mu; Junying Wang; Xueting Bai; Fujuan Xu; Haixia Liu; Jiang Yang; Yaqi Jing; Lingfang Liu; Xuhui Xue; Haitao Dai; Qiang Liu; Yuan-Ming Sun; Changlong Liu*; Xiao-Dong Zhang*, Black Phosphorus Quantum Dot Induced Oxidative Stress and Toxicity in Living Cells and Mice. ACS Appl. Mater. Interfaces 2017, 9, 20399-20409.
15. Junying Wang#; Xiaoyu Mu#; Yonghui Li; Fujuan Xu; Wei Long; Jiang Yang; Peixian Bian; Junchi Chen; Lufei Ouyang; Haile Liu; Yaqi Jing; Jingya Wang; Lingfang Liu; Haitao Dai; Yuanming Sun; Changlong Liu; Xiao-Dong Zhang*, Hollow PtPdRh Nanocubes with Enhanced Catalytic Activities for in Vivo Clearance of Radiation-Induced ROS via Surface-Mediated Bond Breaking. Small 2018, 14, e1703736. (co-First)
16. Jiahui Pei#; Ruoli Zhao#; Xiaoyu Mu#; Junying Wang; Changlong Liu*; Xiao-Dong Zhang*, Single-atom nanozymes for biological applications. Biomater. Sci. 2020, 8, 6428-6441. (co-First)
17. Haile Liu, Yonghui Li, Si Sun, Qi Xin, Shuhu Liu, Xiaoyu Mu, Xun Yuan, Ke Chen, Hao Wang, Kalman Varga, Wenbo Mi, Jiang Yang & Xiao-Dong Zhang*, Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions, Nature Communications, 2021.(提出团簇酶Clusterzyme的概念,揭示对神经炎症的调控, 入选Nature Communications的Editor Choice，入选ESI高被引)
http://news.tju.edu.cn/info/1003/54635.htm
18. Shaofang Zhang, Haiyan Ruan, Qi Xin, Xiaoyu Mu*, Hao Wang*, Xiao-Dong Zhang*, Modulation of the biocatalytic activity and selectivity of CeO2 nanozymes via atomic doping engineering, Nanoscale, 2023, 15, 4408–4419.
19. Haile Liu, Guosong Hong, Zhentao Luo, Junchi Chen, Junlei Chang, Ming Gong, Hua He, Jiang Yang, Xun Yuan, Lulin Li, Xiaoyu Mu, Junying Wang, Wenbo Mi, Jian Luo, Jianping Xie*, Xiao-Dong Zhang*, Atomic-Precision Gold Clusters for NIR-II Imaging. Adv. Mater. 2019, 31, e1901015.
20. Jiangang Xu; Ru Cai; Yunguang Zhang; Xiaoyu Mu*, Molybdenum disulfide-based materials with enzyme-like characteristics for biological applications. Colloid Surface B. 2021, 200, 111575.
21. Qifeng Li, Yalong Gao, Jun Shen, Xiaoyu Mu*, Junying Wang, Lufei Ouyang, Ke Chen, Hua He, Jiahui Pei, Qinjuan Ren, Si Sun, Haile Liu, Lei Zhou, Yuanming Sun, Wei Long, Jianning Zhang*, Xiao-Dong Zhang*. Catalase-like quantum dots of l-lysine polymerization as free radical scavengers for hypoxic brain injury. Mater. Today. Commun. 2021, 27, 102286.
22. Ruijuan Yan#, Si Sun#, Jiang Yang#, Wei Long, Junying Wang, Xiaoyu Mu, Qifeng Li, Wenting Hao, Shaofang Zhang, Haile Liu, Yalong Gao, Lufei Ouyang, Junchi Chen, Shuangjie Liu, Xiao-Dong Zhang*, Dong Ming*, Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma. ACS Nano 2019, 13, 11552-11560.
23. Xiaoyu Mu; Xiaoyu Liu; Xiaohu Wang; Haitao Dai; Changlong Liu*, Growth of Rutile TiO2 Nanorods in Ti and Cu Ion Sequentially Implanted SiO2 and the Involved Mechanisms. Nanotechnology 2018, 29, 025601.
专利：
1. 张晓东, 闫瑞娟, 孙思, 穆晓宇, 刘爽杰. 一种用于皮肤创伤的单原子纳米酶贴剂及制备方法[P]. 天津市：CN110960552A, 2020-04-07.
2. 张晓东, 穆晓宇, 陈珂, 刘青山, 宫晓群. 信号增强的免疫层析试纸及其检测方法和应用[P]. 202411117100.2, 2024-08-15
3. 张晓东, 穆晓宇, 刘晓宇, 万振. 金属单原子纳米酶、其制备方法和应用[P]. 202410450895.2, 2024-04-15
科研项目：，
1. 国家自然科学基金，青年项目， Cu-N-C单原子纳米酶神经绷带的构建及其非入侵治疗(82001952)，24万，2021.1-2023.12，主持，在研。
2. 国家重点研发计划，生物与信息融合（BT-IT融合）重大专项，新一代高相容性生物植入电极设计与应用——课题2“人工酶电极传感系统的研制与性能研究”，54.69万，2021.12-2024.11，主持，在研。
3. “脑科学与类脑研究”重大项目，青年科学家项目，基于忆阻器神经形态芯片的新型脑机接口技术与应用，50万，2022.1-2026.12，项目骨干，在研。
4. 天津市自然科学基金，面上项目，基于新型抗氧化有机纳米酶分子的神经外用绷带，10万，2020.4-2023.3，合作主持，在研。
5. 天津市自然科学基金，面上项目，新型纳米酶对StandfordA型主动脉夹层术后神经系统的保护作用研究，10万，2021.4-2024.3，合作主持，在研。
6. 国家自然科学基金，面上项目，有机纳米酶分子的设计及其对外伤性脑损伤的治，55万，2020.1-2023.12，项目骨干，在研。
7. 国家自然科学基金，联合基金，电子辐射诱导增强CeO2团簇的电催化性能、催化机理及其在脑损伤中的应用，58万，2020.1-2022.12，项目骨干，在研。
8. 国家自然科学基金，重大研究计划培育项目，乳腺癌演进和分子分型的红外二区荧光成像（91859101），70万，2019.1-2021.12，项目骨干，结题。