个人简介

陈元园，工学博士，副研究员/正高级工程师。于天津大学获得学士、硕士和博士学位，2018~2020年在美国西达赛奈医学中心(Cedars-Sinai Medical Center)从事博士后工作。致力于磁共振脑影像分析处理和脑网络算法研究，利用多模态神经影像技术（包括MRI, fNIRS, EEG等），探究大脑功能、结构等多维信息的动态运作机制，揭示年龄、疾病、环境等因素与大脑功能结构特征，及其与行为认知之间的复杂联系。至今已在Cerebral Cortex, Human Brain Mapping, Frontiers in Ageing Neuroscience等期刊发表SCI论文40余篇，授权发明专利7项，获省部级科技奖励两项，指导学生获得天津市工程专业学位硕士研究生优秀论文，主持和参与包括国家重点研发计划、国自然在内的多项科研项目。

主要研究方向

  脑影像与脑连接组学研究

  脑发育/脑老化与行为认知研究

  神经系统疾病的诊治与评估研究

代表性学术成果

论文

1. 刘爽, 俞靖, 陈元园*, 范秋筠, 赵欣,  明东. (2024). 基于多模态影像的脑龄预测模型与应用，生物医学工程学杂志, 43(01), 98-105.

2. Reid Blanchett, Yuanyuan Chen, Fernando Aguate, Kai Xia, Emil Cornea, S Alexandra Burt, Gustavo de Los Campos, Wei Gao, John H Gilmore, Rebecca C Knickmeyer*. (2023). Genetic and environmental factors influencing neonatal resting-state functional connectivity. Cerebral Cortex, 33(8), 4829-4843.

3. Jianlin Guo#, Yuanyuan Chen#, Wen Liu#, Lijuan Huang, Di Hu, Yanqiu Lv, Huiying Kang, Ningdong Li*, Yun Peng*. (2023). Alterations of large‐scale functional network connectivity in patients with infantile esotropia before and after surgery. Brain and Behavior, 13(8), e3154.

4. Yuanyuan Chen#, Chunfang Wang#, Peiqing Song, Changcheng Sun, Ying Zhang*, Xin Zhao*, Jingang Du, (2022). Alpha rhythm of electroencephalography was modulated differently by three transcranial direct current stimulation protocols in patients with ischemic stroke. Frontiers in Human Neuroscience, 16, 887849.

5. Jianlin Guo#, Yuanyuan Chen#, Lijuan Huang #, Wen Liu, Di Hu, Yanqiu Lv, Huiying Kang, Ningdong Li*, Yun Peng*. (2022). Local structural-functional connectivity decoupling of caudate nucleus in infantile esotropia. Frontiers in Neuroscience, 16, 1098735.

6. Jianlin Guo#, Yuanyuan Chen#, Wen Liu #, Lijuan Huang, Di Hu, Yanqiu Lv, Huiying Kang, Ningdong Li*, Yun Peng*, (2022). Abnormal developmental trends of functional connectivity in young children with infantile esotropia. Frontiers in Neuroscience, 16, 972882.

7. Haitao Chen, Janelle Liu, Yuanyuan Chen, Andrew Salzwedel, Emil Cornea, John H. Gilmore, Wei Gao*, (2021), Developmental heatmaps of brain functional connectivity from newborns to 6-year-olds, Developmental Cognitive Neuroscience, 50. 

8. Janelle Liu, Yuanyuan Chen, Rebecca Stephens, Emil Cornea, Barbara Goldman, John H. Gilmore, Wei Gao*. (2021). Hippocampal Functional Connectivity Development During the First Two Years Indexes 4-year Working Memory Performance. Cortex,138, 156-177.

9. Yuanyuan Chen, Shuxin Liu, Andrew Salzwedel, Rebecca Stephens, Emil Cornea, Barbara D Goldman, John H Gilmore, Wei Gao*. (2020). The Subgrouping Structure of Newborns with Heterogenous Brain-Behavior Relationships. Cerebral Cortex. 31(1), 301-311.

10. Wei Gao*, Yuanyuan Chen, Emil Cornea, Barbara D. Goldman, John H. Gilmore. (2020). Neonatal brain connectivity outliers identify over forty percent of IQ outliers at 4 years of age. Brain and Behavior, e01846.

11. Andrew Salzwedel, Gang Chen, Yuanyuan Chen, Karen Grewen*, Wei Gao*. (2020). Functional dissection of prenatal drug effects on baby brain and behavioral development. Human brain mapping, 41(17), 4789-4803. (cover image) 

12. Yuanyuan Chen, Ya-nan Liu, Peng Zhou, Xiong Zhang, Qiong Wu, Xin Zhao*, Dong Ming*. (2019). The transitions between dynamic micro-states reveal age-related functional network reorganization. Frontiers in Physiology, 9, 1852.

13. Mingge Li, Yuanyuan Chen, Zhiye Chen, Jie Feng, Mengyu Liu, Xin Lou, Siyun Shu, Zhenfu Wang*, Lin Ma*., (2019). Altered functional connectivity of the marginal division in parkinson's disease with mild cognitive impairment: a pilot resting state fmri study. Journal of Magnetic Resonance Imaging. 50(pt1).

14. Yuanyuan Chen, Xin Zhao, Xiong Zhang, Ya’nan Liu, Peng Zhou, Hongyan Ni, Jianguo Ma & Dong Ming*. (2018). Age-related early/late variations of functional connectivity across the human lifespan. Neuroradiology, 60(4), 403-412.

15. Yuanyuan Chen, Weiwei Wang, Xin Zhao*, Miao Sha, Ya’nan Liu, Xiong Zhang, Jianguo Ma, Hongyan Ni, Dong Ming*. (2017). Age-related decline in the variation of dynamic functional connectivity: a resting state analysis. Frontiers in aging neuroscience, 9, 203.

16. Yuanyuan Chen, Miao Sha, Xin Zhao, Jianguo Ma, Hongyan Ni*, Wei Gao, Dong Ming*, (2017). Automated detection of pathologic white matter alterations in Alzheimer's disease using combined diffusivity and kurtosis method. Psychiatry Research: Neuroimaging, 264, 35-45.

在研项目

1. 国家自然科学基金青年项目，婴幼儿脑功能网络的个体化发育模式与群体发育异质性研究， 2023.1-2025.12，主持，在研；

2. 国家重点研发计划项目，人体组织结构功能特征无创检测和信息提取的关键技术，2023.11-2026.10，参与（参与单位负责人），在研；

3. 天津市自然科学基金多元投入重点项目，基于MR影像联合机器学习对阿尔茨海默病早期诊断和病程评估，2021.10-2024.9，参与（合作单位负责人），在研；

4. 天津大学自主创新基金，脑结构-功能网络跨时空尺度的动态耦合机制与模型研究，2024.1-2024.12，主持，在研。

获奖情况

1. 2022年，天津大学2022届本科毕业设计（论文）优秀指导教师

2. 2018年，天津大学优秀博士学位论文基金

3. 2018年，天津市科学技术进步二等奖（第五完成人）

4. 2015年，天津市科学技术进步二等奖（第四完成人）

社会学术兼职

中国生物医学工程学会康复会员

中国图像图形学会脑图谱专委会会员

中国妇幼健康研究会婴幼儿心理健康专委会委员