个人简介

天津大学长聘教授，博士生导师，智能医学工程教育部工程研究中心副主任。国家优青，科睿唯安“全球高被引科学家”（Highly Cited Researchers），全球前2%顶尖科学家，爱思唯尔（Elsevier）中国高引学者，天津市高层次人才-“海河英才”。博士毕业于中国科学院与哈佛大学。重点针对癌症、神经系统疾病、组织/器官损伤等临床面临的棘手问题，融合材料学、生物学、医学的研究，设计开发具有良好生物相容性与生物活性的智能材料，发展新型生物制造工艺，研究其在生命系统中的行为与作用，探索针对癌症、神经系统疾病、组织/器官损伤以及其他重大疾病的创新治疗策略。以第一/通讯作者在Sci. Adv.、Nat. Commun.、PNAS、Matter、Adv. Mater.、Angew. Chem. Int. Edit.、Chem. Soc. Rev.等学术期刊发表论文60余篇, 所发表论文他引6500余次，其中23篇论文入围“ESI高被引论文”。申请和授权国内外发明专利20余项，获得Nanoscale Emerging Investigators、Wiley & Exploration优秀青年科学家、华夏医学科技奖等科技奖励。主持国家自然科学基金优秀青年基金、面上项目、青年科学基金项目、省市科技项目等10余项。应邀担任Exploration、Biomedical Technology副主编、The Innovation、Asian Journal of Pharmaceutical Sciences、Chinese Chemical Letters、Nanomaterials、Current Pharmaceutical Design等SCI期刊编委/青年编委。担任国家自然科学基金、科技部重点研发计划、广东省、河南省、天津市、广州市、深圳市等科学基金项目会评/函评专家。

主要研究方向

1.智能医用微纳机器人的设计与开发

（1）基于Janus异质结构的静脉注射纳米机器人，全身血液循环、精准靶向制导，用于癌症、神经系统疾病（脑损伤、阿尔兹海默病等）、炎症等疾病的精准靶向治疗。

（2）基于肠道微生物的口服微纳机器人，消化道循环、精准靶向腔道病变微环境，用于治疗消化道肿瘤、炎症、损伤，以及脑-肠轴效应研究。

2.先进生物医用材料与器械的开发研制

（1）利用3D打印与其他先进制造技术制备智能医用生物材料，包括智能纳米材料、伤口敷料、人造神经、人造血管、人造器官等。

（2）基于智能诊疗技术，开发便携式、可穿戴疾病诊疗设备与器件。

3.肿瘤神经科学：中枢神经系统与全身肿瘤关系网络图谱绘制

（1）绘制大脑与肿瘤之间的关系网络，解析大脑在肿瘤发生发展中所扮演的角色，明确中枢神经系统、免疫系统、肿瘤三者之间的互作关系。

（2）从神经学的角度出发，开发肿瘤治疗的高端技术手段，开拓癌症的神经学治疗新篇章。

……欢迎相关研究背景、领域的硕士生、博士生、博士后以及老师们加入！

主讲课程：

智能医学材料、基础化学（医）……

代表性学术成果

以第一/通讯作者发表论文60余篇，包括7篇Nature/Science/Cell子刊、PNAS，主要代表作如下：

2023

1.Xue Yuan, Yong Kang, Jinrui Dong, Ruiyan Li, Jiamin Ye, Yueyue Fan, Jingwen Han, Junhui Yu, Xiaoyuan Ji*. Self-Triggered Thermoelectric Nano-Heterojunction for Cancer Catalytic/Immuno-Therapy. Nature Communications, 2023, In Press.

2.Fan Zhang, Yong Kang, Liwen Feng, Guan Xi, Na Kong, Wei Tao, Tiangang Luan, Seyoung Koo, Xiaoyuan Ji*. Diabetic Wound Repair with an Ultrasound-enhanced Nanozyme Hydrogel Scaffold. Materials Horizons, 2023, In Press.

3.Qinzhen Cheng, Yong Kang, Bin Yao, Jinrui Dong, Yalan Zhu, Yiling He, Xiaoyuan Ji*. Genetically Engineered-Cell Membrane Nanovesicles for Cancer Immunotherapy. Advanced Science, 2023, 2302131.

4.Yichu Nie, Wei Chen, Yong Kang, Xue Yuan, Yongjiang Li, Jun Zhou, Wei Tao, Xiaoyuan Ji*. Two-dimensional porous vermiculite-based nanocatalysts for synergetic catalytic therapy. Biomaterials, 2023, 295, 122031.

5.Yong Kang, Lingling Xu, Jinrui Dong, Yongzhi Huang, Xue Yuan, Ruiyan Li, Liqun Chen, Zhen Wang, Xiaoyuan Ji*. Calcium-based nanotechnology for cancer therapy. Coordination Chemistry Reviews, 2023, 481, 215050.

6.Shengjie Sun, Mian Yu, Liu Yu, Wenxin Huang, Meishu Zhu, Yanan Fu, Lingchen Yan, Qiang Wang, Xiaoyuan Ji*, Jing Zhao, Meiying Wu. Nrf2 silencing amplifies DNA photooxidative damage to activate the STING pathway for synergistic tumor immunotherapy. Biomaterials, 2023, 296, 122068.

7.Yong Kang, Na Kong, Meitong Ou, Ying Wang, Qicai Xiao, Lin Mei, Bing Liu, Liqun Chen, Xiaobin Zeng, Xiaoyuan Ji*. A Novel Cascaded Energy Conversion System Inducing Efficient and Precise Cancer Therapy. Bioactive Materials, 2023, 20, 663-676.

8.Hanjie Zhang, Zhuo Mao, Yong Kang, Wen Zhang, Lin Mei, Xiaoyuan Ji*. Redox regulation and its emerging roles in cancer treatment. Coordination Chemistry Reviews, 2023, 475, 214897.

9.Xiaoyuan Ji,* Zhongmin Tang, Haijun Liu, Yong Kang, Liqun Chen, Jinrui Dong, Wei Chen, Na Kong, Wei Tao, Tian Xie. Nanoheterojunction-Mediated Thermoelectric Strategy for Cancer Surgical Adjuvant Treatment and β-elemene Combination Therapy. Advanced Materials, 2023, 35, 2207391.

2022

1.Liqun Chen, Zhuo Mao, Yang Wang, Yong Kang, Ying Wang, Lin Mei, Xiaoyuan Ji*. Edge Modification Facilitated Heterogenization and Exfoliation of Two-Dimensional Nanomaterials for Cancer Catalytic Therapy. Science Advances, 2022, 8, eabo7372.

2.Yong Kang, Zhuo Mao, Ying Wang, Chao Pan, Meitong Ou, Hanjie Zhang, Xiaoyuan Ji*. Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy. Nature Communications, 2022, 13, 2425.

3.Yong Kang, Hanjie Zhang, Liqun Chen, Jinrui Dong, Bin Yao, Xue Yuan, Duotian Qin, Alexey V. Yaremenko, Chuang Liu, Chan Feng, Xiaoyuan Ji,* Wei Tao. The marriage of Xenes and Hydrogels: Fundamentals, Applications, and Outlook. The Innovation, 2022, 3, 100327.

4.Yichu Nie, Weilang Zhang, Wenqing Xiao, Weiwei Zeng, Ting Chen, Weiqiang Huang, Xixi Wu, Yong Kang, Jinrui Dong, Wei Luo, Xiaoyuan Ji*. Novel biodegradable two-dimensional vanadene augmented photoelectro-fenton process for cancer catalytic therapy. Biomaterials, 2022, 289, 121791.

5.Meitong Ou, Chuchu Lin, Ying Wang, Yuting Lu, Wenyan Wang, Zimu Li, Weiwei Zeng, Xiaowei Zeng, Xiaoyuan Ji*, Lin Mei. Heterojunction engineered bioactive chlorella for cascade promoted cancer therapy, Journal of Controlled Release, 2022, 345, 755.

6.Weiwei Zeng, Hanjie Zhang, Xue Yuan, Ting Chen, Zhengcun Pei, Xiaoyuan Ji*. Two-Dimensional Nanomaterial-based catalytic Medicine: Theories, advanced catalyst and system design. Advanced Drug Delivery Reviews, 2022, 184, 114241.

7.Chao Pan, Zhuo Mao, Xue Yuan, Hanjie Zhang, Lin Mei, Xiaoyuan Ji*. Heterojunction Nanomedicine, Advanced Science, 2022, 9, 2105747.

2021

1.Na Kong, Hanjie Zhang, Chan Feng, Chuang Liu, Yufen Xiao, Lin Mei, Wei Tao, Xiaoyuan Ji*. Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy, Nature Communications, 2021, 12, 4777. 

2.Xiaoyuan Ji, Lanlan Ge, Liu Chuang, Zhongmin Tang, Yufen Xiao, Wei Chen, Zhouyue Lei, Wei Gao, Sara Blake, Diba De, Bingyang Shi, Xiaobing Zeng, Na Kong, Xingcai Zhang, Wei Tao*. Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics, Nature Communications, 2021, 12: 1124.

3.Yong Kang, Lei Lei, Chunfeng Zhu, Hanjie Zhang, Lin Mei, Xiaoyuan Ji*. Piezo-photocatalytic effect mediating reactive oxygen species burst for cancer catalytic therapy, Materials Horizons, 2021, 8, 2273.

4.Meitong Ou, Liu Yu, Wei Tao, Xiaoyuan Ji*, Lin Mei. The Emergence and Evolution of Borophene. Advanced Science, 2021, 2001801.

2020

1.Chan Feng, Jiang Ouyang, Zhongmin Tang, Na Kong, Yuan Liu, Liyi Fu, Xiaoyuan Ji*, Tian Xie, Omid C. Farokhzad, Wei Tao. Germanene-Based Theranostic Materials for Surgical Adjuvant Treatment: Inhibiting Tumor Recurrence and Wound Infection, Matter, 2020, 3, 127-144.

2.Chao Pan, Meitong Ou, Qinzhen Cheng, Yun Zhou, Yongkang Yu, Zimu Li, Fan Zhang, Dehua Xia, Lin Mei, Xiaoyuan Ji*. Z-Scheme Heterojunction Functionalized Pyrite Nanosheets for Modulating Tumor Microenvironment and Strengthening Photo/Chemodynamic Therapeutic Effects, Advanced Functional Materials, 2020, 30, 1906466.

3.Jiang Ouyang#, Xiaoyuan Ji#, Xingcai Zhang, Chan Feng, Zhongmin Tang, Na Kong, Angel Xie, Junqing Wang, Liu Deng, You-Nian Liu, Wei Tao*. In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment, Proceedings of the National Academy of Sciences of the United States of America, 2020, 117, 28667-28677.

4.Meitong Ou, Chao Pan, Yongkang Yu, Xuan Wang, Yun Zhou, Hanjie Zhang, Qinzhen Cheng, Meiying Wu, Xiaoyuan Ji*, Lin Mei. Two-dimensional highly oxidized ilmenite nanosheets equipped with Z-scheme heterojunction for regulating tumor microenvironment and enhancing reactive oxygen species generation, Chemical Engineering Journal, 2020, 390: 124524.

5.Weiwei Zeng, Hanjie Zhang, Yimin Deng, Aiting Jiang, Xiaoyan Bao, Minqi Guo, Zimu Li, Meiying Wu, Xiaoyuan Ji*, Xiaowei Zeng, Lin Mei. Dual-response oxygen-generating MnO2 nanoparticles with polydopamine modification for combined photothermal-photodynamic therapy. Chemical Engineering Journal, 2020, 389, 124494.

6.Yong Kang, Zhengjun Li, Yanli Yang, Zhiguo Su, Xiaoyuan Ji,* Songping Zhang. Antimonene Nanosheets-Based Z-Scheme Heterostructure with Enhanced Reactive Oxygen Species Generation and Photothermal Conversion Efficiency for Photonic Therapy of Cancer. Advanced Healthcare Materials, 2020, 2001835.

7.Xiaoyuan Ji, Yong Kang, Taojian Fan, Zameer Bharwani, Songping Zhang, Wei Tao, Han Zhang. An antimonene/Cp*Rh(phen)Cl/black phosphorus hybrid nanosheet-based Z-scheme artificial photosynthesis for enhanced photo/bio-catalytic CO2 reduction, Journal of Materials Chemistry A, 2020, 8, 323-333.

Before 2020

1.Wei Tao*#, Na Kong#, Xiaoyuan Ji#, Yupeng Zhang, Amit Sharma, Jiang Ouyang, Baowen Qi, Chulhun Kang*, Han Zhang*, Omid C. Farokhzad, Jong Seung Kim*. Emerging Two-dimensional Monoelemental Materials (Xenes) for Biomedical Applications. Chemical Society Reviews, 2019, 48, 2891.

2.Xiaoyuan Ji, Yong Kang, Jiang Ouyang, Yunhan Chen, Dolev Artzi, Xiaobin Zeng*, Yuling Xiao, Chan Feng, Baowen Qi, Na Yoon Kim, Phei Er Saw, Na Kong, Omid C. Farokhzad*, Wei Tao*. Synthesis of Ultrathin Biotite Nanosheets as an Intelligent Theranostic Platform for Combination Cancer Therapy. Advanced Science, 2019, 6, 1901211.

3.Hanjie Zhang, Weiwei Zeng, Chao Pan, Liwen Feng, Meitong Ou, Xiaowei Zeng, Xin Liang, Meiying Wu, Xiaoyuan Ji*, Lin Mei. SnTe@MnO2-SP Nanosheets based Intelligent Nano-platform for Second Near-Infrared Light Mediated Cancer Theranostics. Advanced Functional Materials, 2019, 29, 1903791.

4.Xiaoyuan Ji, Jie Wang, Yong Kang, Lin Mei, Zhiguo Su, Shaomin Wang, Guanghui Ma, Jinjun Shi*, Songping Zhang*. Enhanced Solar Energy Harvest and Electron Transfer through Intra- and Intermolecular Dual Channels in Chlorosome-Mimicking Supramolecular Self-Assemblies. ACS Catalysis, 2018, 8, 10732-10745.

5.Wei Tao#, Xiaoyuan Ji#,Xianbing Zhu, Li Li, Junqing Wang, Ye Zhang, Phei Er Saw, Wenliang Li, Na Kong, Mohammad Ariful Islam, Tian Gan, Xiaowei Zeng, Han Zhang, Morteza Mahmoudi, Guillermo J. Tearney, and Omid C. Farokhzad* Two-Dimensional Antimonene-based Photonic Nanomedicine for Cancer Therapy. Advanced Materials, 2018, 30, 1802061.

6.Xiaoyuan Ji, Na Kong, Junqing Wang, Wenliang Li, Yuling Xiao, Silvia Tian Gan, Ye Zhang, Yujing Li, Xiangrong Song, Qingqing Xiong, Sanjun Shi, Zhongjun Li, Wei Tao, Han Zhang*, Lin Mei*, Jinjun Shi*. A Novel Top-Down Synthesis of Ultrathin Two-Dimensional Boron Nanosheets for Multi-modal Imaging-Guided Cancer Therapy. Advanced Materials, 2018, 30, 1803031.

7.Xiaoyuan Ji, Jie Wang, Lin Mei, Wei Tao, Austin Barrett, Zhiguo Su, Shaomin Wang, Guanghui Ma, Jinjun Shi*, Songping Zhang*. Porphyrin/SiO2/Cp*Rh(bpy)Cl Hybrid Nanoparticles Mimicking Chloroplast with Enhanced Electronic Energy-Transfer Across Molecular Wires for Biocatalyzed Artificial Photosynthesis. Advanced Functional Materials, 2018, 28, 1705083.

8.Xianbing Zhu#, Xiaoyuan Ji#, Na Kong, Yunhan Chen, Morteza Mahmoudi, Xiaoding Xu, Li Ding, Wei Tao*, Ting Cai, Yujing Li, Tian Gan, Austin Barrett, Zameer Bharwani, Hongbo Chen, Omid C. Farokhzad*. Intracellular Mechanistic Understanding of 2D MoS2 Nanosheets for Anti-Exocytosis-Enhanced Synergistic Cancer Therapy. ACS Nano, 2018, 12, 2922–2938.

9.Yanlan Liu#, Xiaoyuan Ji#, Jianhua Liu, Winnie W. L. Tong, Diana Askhatova, Jinjun Shi*. Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy. Advanced Functional Materials. 2017, 27, 1703261.

10.Wei Tao#, Xiaoyuan Ji#, Xiaoding Xu, Mohammad Ariful Islam, Zhongjun Li, Si Chen, Phei Er Saw, Han Zhang,* Zameer Bharwani, Zilei Guo, Jinjun Shi,* Omid C. Farokhzad*. Antimonene Quantum Dots: Synthesis and Application as Near-Infrared Photothermal Agents for Effective Cancer Therapy. Angewandte Chemie International Edition, 2017, 56, 1-6.

11.Xiaoyuan Ji, Cuicui Liu, Jie Wang, Zhiguo Su, Guanghui Ma, Songping Zhang*. Integration of Functionalized Two-Dimensional TaS2 Nanosheets and Electron Mediator for More Efficient Biocatalyzed Artificial Photosynthesis. Journal of Materials Chemistry A, 2017, 5, 5511-5522.

12.Xiaoyuan Ji, Zhiguo Su, Ping Wang, Guanghui Ma, Songping Zhang*. Integration of Artificial Photosynthesis System for Enhanced Electronic Energy-Transfer Efficacy: A Case Study for Solar-Energy Driven Bioconversion of Carbon Dioxide to Methanol. Small, 2016, 12, 4753–4762. 

13.Xiaoyuan Ji, Zhiguo Su, Ping Wang, Guanghui Ma, Songping Zhang*. Tethering of Nicotinamide Adenine Dinucleotide Inside Hollow Nanofibers for High-Yield Synthesis of Methanol from Carbon Dioxide Catalyzed by Co-Encapsulated Multienzymes. ACS Nano, 2015, 9, 4600–4610. 

14.Xiaoyuan Ji, Zhiguo Su, Ping Wang, Guanghui Ma, Songping Zhang*. Polyelectrolyte Doped Hollow Nanofibers for Positional Assembly of Bienzyme System for Cascade Reaction at O/W Interface. ACS Catalysis, 2014, 4, 4548-4559.

科研项目

1.国家自然科学基金委员会，优秀青年项目，2022-01至2024-12，200万，在研，主持

2.国家自然科学基金委员会，面上项目， 2021-01至2024-12，62万元，在研，主持

3.国家自然科学基金委员会，青年项目， 2019-01至2021-12，21万，结题，主持

4.天津市科学技术局，重点项目，2023-01至2025-12，20万，在研，主持

5.天津市共建师资队伍， 2021-01至2023-12，100万，在研，主持

6.天津大学自主创新基金， 2021-01至2021-12，30万，结题，主持

7.深圳市科技创新委员会，面上项目，2021-01至2023-12，50万，在研，主持

8.深圳市科技创新委员会，面上项目，2019-01至2021-12，50万，结题，主持

9.中山大学高校基本业务费，青年教师培育项目，2020-01至2022-12，20万，结题，主持

10.国家自然科学基金委员会，面上项目，21676276，2017-01至2020-12，64万元，结题，参加

11.国家自然科学基金委员会，重大研究计划，91534126，2016-01至2018-12，80万元，结题，参加

12.国家自然科学基金委员会，面上项目，21376249，2014-01至2017-12，80万元，已结题，参加

获奖情况

1.2023，Nanoscale Emerging Investigators

2.2023，Wiley & Exploration优秀青年科学家

3.2022，科睿唯安“全球高被引科学家”

4.2022，全球前2%顶尖科学家

5.2022，爱思唯尔中国高引学者

6.2021，国家优青

7.2021，天津市海河英才

8.2021，天津大学北洋英才

9.2020，华夏医学科技奖

10.2017，中国教育部国家奖学金

11.2017，中国科学院地奥奖学金

12.2016，中国科学院地奥奖学金

13.2016，中国科学院过程工程研究所所长奖

14.2015，中国教育部国家奖学金

15.2015，国家留学基金委留学基金

16.2015，中国科学院过程工程研究所所长奖

17.2014，中国科学院过程工程研究所所长奖

18.2010，省级优秀毕业生

社会学术兼职

1.国家自然科学基金委会评/函评专家

2.科技部重点研发计划会评/函评专家

3.广东省/河南省/天津市等多省市科技厅会评/函评专家

4.杭州师范大学“钱塘学者”特聘教授（兼）

5.临沂大学高层次特聘教授（兼）

6.中山大学附属第一医院特聘教授（兼）

7.Exploration、Biomedical Technology副主编

8.Frontiers in Materials、Current Pharmaceutical Design等杂志客座主编

9.The Innovation、Asian Journal of Pharmaceutical Sciences、Chinese Chemical Letters、Nanomaterials、Current Pharmaceutical Design等SCI期刊编委/青年编委

10.审稿人：Nature Communications、Science Advances, Advanced Materials, Angewandte Chemie International Edition, ACS Nano, Advanced Functional Materials, Advanced Science, Small, Biomaterials等.